Dense array EEG research on neurological disorders, such as epilepsy and schizophrenia, has suggested that, in some cases, the neuropathology of the disorder may be seen most clearly during sleep. To research the neurophysiology of these disorders, we need a better understanding of the neural mechanisms of normal sleep.
Seizures in Sleep
In our studies of nocturnal onset seizures, we have observed the remarkable effect of seizures emerging from the normal neurophysiological phenomenon of cortical slow oscillations of sleep.
Sleep Disorder in Schizophrenia
Research at Wisconsin Sleep has shown the importance of dense array EEG in characterizing the sleep disorders of schizophrenia.
Ferrarelli, F., Huber, R., Peterson, M.J., Massimini, M., Riedner, B.A. et al.(2007). Reduced sleep spindle activity in schizophrenia patients. Am J Psychiatry, 164(3), 483-492.