Doing Research with High Density EEG

For many researchers, a first issue is how their research question could be addressed by High Density EEG. With over 1400 research papers using EGI's technology, there is now an extensive literature on unique and creative applications of High Density EEG to research in human neuroscience.

To give some examples of these applications, we sorted EGI customer publications from 2007 to June 2008 into 20 topics. A full list of EGI Customer Publications is available here.


Giabbiconi, C. M., Trujillo-Barreto, N. J., Gruber, T., & Muller, M. M. (2007). Sustained spatial attention to vibration is mediated in primary somatosensory cortex. Neuroimage, 35(1), 255-262.

Tata, M. S., Mason, A. L., & Sutherland, R. J. (2007). Attention modulates responses to motion reversals in human visual cortex. Neuroreport, 18(13), 1361-1365.

Wang, J., Clementz, B. A., & Keil, A. (2007). The neural correlates of feature-based selective attention when viewing spatially and temporally overlapping images. Neuropsychologia, 45(7), 1393-1399.

Schupp, H. T., Stockburger, J., Bublatzky, F., Junghofer, M., Weike, A. I., & Hamm, A. O. (2007). Explicit attention interferes with selective emotion processing in human extrastriate cortex. BMC Neurosci, 8, 16.


Holroyd, C. B. & Coles, M. G. (2008). Dorsal anterior cingulate cortex integrates reinforcement history to guide voluntary behavior. Cortex, 44(5), 548-559.

Galgano, J. & Froud, K. (2008). Evidence of the voice-related cortical potential: An electroencephalographic study. Neuroimage, 41(4), 1313-1323.

Clapp, W. C., Johnson, B. W., & Hautus, M. J. (2007). Graded cue information in dichotic pitch: effects on event-related potentials. Neuroreport, 18(4), 365-368.

Schnider, A., Mohr, C., Morand, S., & Michel, C. M. (2007). Early cortical response to behaviorally relevant absence of anticipated outcomes: a human event-related potential study. Neuroimage, 35, 1348-1355.

Johnson, B. W., Hautus, M. J., Duff, D. J., & Clapp, W. C. (2007). Sequential processing of interaural timing differences for sound source segregation and spatial localization: evidence from event-related cortical potentials. Psychophysiology, 44(541-551).

Hestvik, A., Maxfield, N., Schwartz, R. G., & Shafer, V. (2007). Brain responses to filled gaps. Brain and Language, 100, 301-316.

Akyürek, E. G., Riddell, P. M., Toffanin, P., & Hommel, B. (2007). Adaptive control of event integration: evidence from event-related potentials. Psychophysiology, 44.


Speer, N. K. & Curran, T. (2007). ERP correlates of familiarity and recollection processes in visual associative recognition. Brain Res, 1174, 97-109.

Curran, T., DeBuse, C., & Leynes, P. A. (2007). Conflict and criterion setting in recognition memory. J Exp Psychol Learn Mem Cogn, 33(1), 2-17.

Curran, T. & Hancock, J. (2007). The FN400 indexes familiarity-based recognition of faces. Neuroimage, 86, 464-471.

Agam, Y. & Sekuler, R. (2007). Interactions between working memory and visual perception: an ERP/EEG study. Neuroimage, 36, 933-942.


Nikolaev, A. R., Gepshtein, S., Kubovy, M., & van Leeuwen, C. (2008). Dissociation of early evoked cortical activity in perceptual grouping. Exp Brain Res, 186(1), 107-122.

Pitts, M. A., Gavin, W. J., & Nerger, J. L. (2008). Early top-down influences on bistable perception revealed by event-related potentials. Brain Cogn, 67(1), 11-24.

van der Meer, A. L., Fallet, G., & van der Weel, F. R. (2008). Perception of structured optic flow and random visual motion in infants and adults: a high-density EEG study. Exp Brain Res, 186(3), 493-502.

Reiss, J. E. & Hoffman, J. E. (2007). Disruption of early face recognition processes by object substitution masking. Visual Cognition, 15, 789-798.

Pitts, M. A., Nerger, J., & Davis, J. R. T. (2007). Electrophysiological correlates of perceptual reversals for three different types of multi-stable images. Journal of Vision, 7, 1-14.

Human Learning and Performance

Serrien, D. J. (2008). The neural dynamics of timed motor tasks: evidence from a synchronization-continuation paradigm. Eur J Neurosci, 27(6), 1553-1560.

Serrien, D. J. (2008). Coordination constraints during bimanual versus unimanual performance conditions. Neuropsychologia, 46(2), 419-425.

Nikolaev, A. R., Ziessler, M., Dimova, K., & van Leeuwen, C. (2008). Anticipated action consequences as a nexus between action and perception: evidence from event-related potentials. Biol Psychol, 78(1), 53-65.

Duncan, E. A., Jackson, G. M., & Swainson, R. (2008). Fractionating the cognitive control required to bring about a achange in task: a dense-sensor event-related potential study. Journal of Cognitive Neuroscience, 20, 255-267.

Rossion, B., Collins, D., Goffaux, V., & Curran, T. (2007). Long-term expertise with artificial objects increases visual competition with early face categorization processes. J Cogn Neurosci, 19(3), 543-555.

Tzur, G. & Berger, A. (2007). When things look wrong: theta activity in rule violation. Neuropsychologia, 45(3122-3126).

Luu, P., Tucker, D. M., & Stripling, R. (2007). Neural mechanisms for learning actions in context. Brain Research, 1179, 89-105.


Arzouan, Y., Goldstein, A., & Faust, M. (2007). Dynamics of hemispheric activity during metaphor comprehension: electrophysiological measures. Neuroimage, 36(1), 222-231.

Arzouan, Y., Goldstein, A., & Faust, M. (2007). Brainwaves are stethoscopes: ERP correlates of novel metaphor comprehension. Brain Research, 1160, 69-81.

Endress, A. D., Dehaene-Lambertz, G., & Mehler, J. (2007). Perceptual constraints and the learnability of simple grammars. Cognition, 105(3), 577-614.

Yang, C. L., Perfetti, C. A., & Schmalhofer, F. (2007). Event-related potential indicators of text integration across sentence boundaries. Journal of Experimental Psychology: Learning, Memory, and Cognition, 33, 55-89.

Franklin, M. S., Dien, J., Neely, J. H., Huber, E., & Waterson, L. D. (2007). Semantic priming modulates the N400, N300, and N400RP. Clinical Neurophysiology, 118, 1053-1068.

Blanchet, S., Gagnon, G., & Bastien, C. (2007). Event-related potential study of dynamic neural mechanisms of semantic organizational strategies in verbal learning. Brain Research, 1170, 59-70.

Social Cognition

Krusemark, E. A., Keith Campbell, W., & Clementz, B. A. (2008). Attributions, deception, and event related potentials: An investigation of the self-serving bias. Psychophysiology.


Deveney, C. M. & Pizzagalli, D. A. (2008). The cognitive consequences of emotion regulation: an ERP investigation. Psychophysiology, 45(3), 435-444.

Flaisch, T., Stockburger, J., & Schupp, H. T. (2008). Affective prime and target picture processing: an ERP analysis of early and late interference effects. Brain Topogr, 20(4), 183-191.

Schupp, H. T., Stockburger, J., Schmalzle, R., Bublatzky, F., Weike, A. I., & Hamm, A. O. (2008). Visual noise effects on emotion perception: brain potentials and stimulus identification. Neuroreport, 19(2), 167-171.

Pastor, M. C., Bradley, M. M., Low, A., Versace, F., Molto, J., & Lang, P. J. (2008). Affective picture perception: emotion, context, and the late positive potential. Brain Res, 1189, 145-151.

Flaisch, T., Junghofer, M., Bradley, M. M., Schupp, H. T., & Lang, P. J. (2008). Rapid picture processing: affective primes and targets. Psychophysiology, 45(1), 1-10.

Santesso, D. L., Meuret, A. E., Hofmann, S. G., Mueller, E. M., Ratner, K. G., Roesch, E. B. et al. (2008). Electrophysiological correlates of spatial orienting towards angry faces: a source localization study. Neuropsychologia, 46(5), 1338-1348.

Lewis, M. D., Todd, R. M., & Honsberger, M. J. (2007). Event-related potential measures of emotion regulation in early childhood. Neuroreport, 18(1), 61-65.

Lewis, R. S., Weekes, N. Y., & Wang, T. H. (2007). The effect of a naturalistic stressor on frontal EEG asymmetry, stress, and health. Biological psychology, 75, 239-247.

Keil, A., Stolarova, M., Moratti, S., & Ray, W. J. (2007). Adaptation in human visual cortex as a mechanism for rapid discrimination of aversive stimuli. Neuroimage, 36, 472-479.

Bradley, M. M., Hamby, S., Löw, A., & Lang, P. J. (2007). Brain potentials in perception: picture complexity and emotional arousal. Psychophysiology, 44, 364-373.

Blau, V. C., Maurer, U., Tottenham, N., & McCandliss, B. D. (2007). The face-specific N170 component is modulated by emotional facial expression. Behav Brain Funct, 3, 7.

Personality and Individual Differences

Santesso, D. L., Segalowitz, S. J., Ashbaugh, A. R., Antony, M. M., McCabe, R. E., & Schmidt, L. A. (2008). Frontal EEG asymmetry and sensation seeking in young adults. Biol Psychol, 78(2), 164-172.

Patston, L. L., Kirk, I. J., Rolfe, M. H., Corballis, M. C., & Tippett, L. J. (2007). The unusual symmetry of musicians: musicians have equilateral interhemispheric transfer for visual information. Neuropsychologia, 45(9), 2059-2065.

Arzy, S., Mohr, C., Michel, C. M., & Blanke, O. (2007). Duration and not strength of activation in temporo-parietal cortex positivitely correlates with schizotypy. Neuroimage, 35, 326-333.

Child Development

Todd, R. M., Lewis, M. D., Meusel, L. A., & Zelazo, P. D. (2008). The time course of social-emotional processing in early childhood: ERP responses to facial affect and personal familiarity in a Go-Nogo task. Neuropsychologia, 46(2), 595-613.

Lippe, S., Roy, M. S., Perchet, C., & Lassonde, M. (2007). Electrophysiological markers of visuocortical development. Cereb Cortex, 17(1), 100-107.

Steiben, J., Lewis, M. D., Granic, I., Zelazo, P. D., Segalowitz, S. J., & Pepler, D. (2007). Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children. Development and Psychopathology, 19, 455-480.

Poulsen, C., Picton, T. W., & Paus, T. (2007). Age-related changes in transient and oscillatory brain responses to auditory stimulation in healthy adults 19-45 years old. Cerebral Cortex, 17, 1454-1467.

Ladouceur, C. D., Dahl, R. E., & Carter, C. S. (2007). Development of action monitoring through adolescence into adulthood: ERP and source localization. Developmental Science, 10, 874-891.


Ferri, R., Huber, R., Arico, D., Drago, V., Rundo, F., Ghilardi, M. F. et al. (2008). The slow-wave components of the cyclic alternating pattern (CAP) have a role in sleep-related learning processes. Neurosci Lett, 432(3), 228-231.

Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A. et al. (2007). Reduced sleep spindle activity in schizophrenia patients. American Journal of Psychiatry, 164, 483-492.


Dubois, J., Dehaene-Lambertz, G., Soares, C., Cointepas, Y., Le Bihan, D., & Hertz-Pannier, L. (2008). Microstructural correlates of infant functional development: example of the visual pathways. J Neurosci, 28(8), 1943-1948.

Izard, V., Dehaene-Lambertz, G., & Dehaene, S. (2008). Distinct cerebral pathways for object indentity and number in human infants. PLoS Biology, 6, 1-11.

van der Meer, A. L., Fallet, G., & van der Weel, F. R. (2008). Perception of structured optic flow and random visual motion in infants and adults: a high-density EEG study. Exp Brain Res, 186(3), 493-502.

Isler, J. R., Grose-Fifer, J., Fifer, W. P., Housman, S., Stark, R. I., & Grieve, P. G. (2007). Frequency domain analyses of neonatal flash VEP. Pediatr Res, 62(5), 581-585.

He, C., Hotson, L., & Trainor, L. J. (2007). Mismatch responses to pitch changes in early infancy. J Cogn Neurosci, 19(5), 878-892.

Arcand, C., Tremblay, E., Vannasing, P., Ouimet, C., Roy, M. S., Fallaha, N. et al. (2007). Development of visual texture segregation during the first year of life: a high-density electrophysiological study. Exp Brain Res, 180(2), 263-272.

Leppanen, J. M., Moulson, M. C., Vogel-Farley, V. K., & Nelson, C. A. (2007). An ERP study of emotional face processing in the adult and infant brain. Child Dev, 78(1), 232-245.

Reid, V. M., Csibra, G., Belsky, J., & Johnson, M. H. (2007). Neural correlates of the perception of goal-directed action in infants. Acta Psychol (Amst), 124(1), 129-138.

Rosander, K., Nyström, P., Gredebäck, G., & von Hofsten, C. (2007). Cortical processing of visual motion in young infants. Vision Research, 47, 1614-1623.

Pivik, R. T., Dykman, R. A., Jing, H., Gilchrist, J. M., & Badger, T. M. (2007). The influence of infant diet on early developmental changes in processing human voice speech stimuli: ERP variations in breast and milk formula-fed infants at 3 and 6 months after birth. Dev Neuropsychol, 31(3), 279-335.

Grieve, P. G., Stark, R. I., Isler, J. R., Housman, S. L., Fifer, W. P., & Myers, M. M. (2007). Electrocortical functional connectivity in infancy: response to body tilt. Pediatric Neurology, 37, 91-98.

Ferguson, M. & Molfese, P. J. (2007). Breast-fed infants process speech differently from bottle-fed infants: evidence from neuroelectrophysiology. Dev Neuropsychol, 31(3), 337-347.


Bernier, R., Dawson, G., Webb, S., & Murias, M. (2007). EEG mu rhythm and imitation impairments in individuals with autism spectrum disorder. Brain Cogn, 64(3), 228-237.

Murias, M., Webb, S. J., Greenson, J., & Dawson, G. (2007). Resting state cortical connectivity reflected in EEG coherence in individuals with autism. Biological Psychiatry, 62, 270-273.

Language Disorders

Hamalainen, J. A., Leppanen, P. H., Guttorm, T. K., & Lyytinen, H. (2008). Event-related potentials to pitch and rise time change in children with reading disabilities and typically reading children. Clin Neurophysiol, 119(1), 100-115.

Fonteneau, E. & van der Lely, H. K. (2008). Electrical brain responses in language-impaired children reveal grammar-specific deficits. PLoS ONE, 3(3), e1832.

Hamalainen, J. A., Leppanen, P. H., Guttorm, T. K., & Lyytinen, H. (2007). N1 and P2 components of auditory event-related potentials in children with and without reading disabilities. Clin Neurophysiol, 118(10), 2263-2275.

Landi, N. & Perfetti, C. A. (2007). An electrophysiological investigation of semantic and phonological processing in skilled and less-skilled comprehenders. Brain Lang, 102(1), 30-45.

Taroyan, N. A., Nicolson, R. I., & Fawcett, A. J. (2007). Behavioural and neurophysiological correlates of dyslexia in the continuous performance task. Clinical Neurophysiology.

Attention Deficit Hyperactivity Disorder

Rolfe, M. H., Kirk, I. J., & Waldie, K. E. (2007). Interhemispheric callosal transfer in adults with attention-deficit/hyperactivity disorder: an event-related potential study. Neuroreport, 18(3), 255-259.

Murias, M., Swanson, J. M., & Srinivasan, R. (2007). Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence. Cereb Cortex, 17(8), 1788-1799.

Rodriguez, P. D. & Baylis, G. C. (2007). Activation of brain attention systems in individuals with symptoms of ADHD. Behav Neurol, 18(2), 115-130.


Lavoie, S., Murray, M. M., Deppen, P., Knyazeva, M. G., Berk, M., Boulat, O. et al. (2008). Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology, 33(9), 2187-2199.

Wood, S. M., Potts, G. F., Martin, L. E., Kothmann, D., Hall, J. F., & Ulanday, J. B. (2007). Disruption of auditory and visual attention in schizophrenia. Psychiatry Res, 156(2), 105-116.

Posada, A., Franck, N., Augier, S., Georgieff, N., & Jeannerod, M. (2007). Altered processing of sensorimotor feedback in schizophrenia. C R Biol, 330(5), 382-388.

Zarkowski, P., Esparza, B., & Russo, J. (2007). Validation of a rational malingering test using evoked potentials. Journal of Clinical Neurophysiology, 24, 413-418.

Jalili, M., Lavoie, S., Deppen, P., Meuli, R., Do, K. Q., Cuenod, M. et al. (2007). Dysconnection topography in schizophrenia revealed with state-space analysis of EEG. PLoS ONE, 2(10), e1059.

Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A. et al. (2007). Reduced sleep spindle activity in schizophrenia patients. American Journal of Psychiatry, 164, 483-492.


Putnam, K. M. & McSweeney, L. B. (2008). Depressive symptoms and baseline prefrontal EEG alpha activity: a study utilizing Ecological Momentary Assessment. Biol Psychol, 77(2), 237-240.

Tucker, D. M. & Luu, P. (2007). Neurophysiology of motivated learning: adaptive mechanisms underlying cognitive bias in depression. Cognitive Therapy and Research, 31, 189-209.

Brain-Computer Interface

Wu, Z. & Yao, D. (2008). Frequency detection with stability coefficient for steady-state visual evoked potential (SSVEP)-based BCIs. J Neural Eng, 5(1), 36-43.

Poolman, P., Frank, R. M., Luu, P., Pederson, S. M., & Tucker, D. M. (2008). A single-trial analytic framework for EEG analysis and its application to target detection and classification. Neuroimage, 42(2), 787-798.

Neurological Disorders

Larson, M. J., Kaufman, A. S., Schmalfuss, I. M., & Perstein, W. M. (2007). Performance monitoring, error processing, and evaluative control following sever TBI. Journal of the International Neuropsychological Society, 13, 961-971.

Tucker, D. M., Brown, M., Luu, P., & Holmes, M. D. (2007). Discharges in ventromedial frontal cortex during absence spells. Epilepsy and Behavior, 11, 546-557.

HD EEG and fMRI Methods

O'Hare, A. J., Dien, J., Waterson, L., & Savage, C. R. (2008). Activation of the posterior cingulate by semantic priming: a co-registered ERP/fMRI study. Brain Research, 1189, 97-114.

Meltzer, J. A., Negishi, M., Mayes, L. C., & Constable, R. T. (2007). Individual differences in EEG theta and alpha dynamics during working memory correlate with fMRI responses across subjects. Clin Neurophysiol, 118(11), 2419-2436.

Sabatinelli, D., Lang, P. J., Keil, A., & Bradley, M. M. (2007). Emotional perception: correlation of functional MRI and event-related potentials. Cereb Cortex, 17(5), 1085-1091.

Min, B. K., Busch, N. A., Debener, S., Kranczioch, C., Hanslmayr, S., Engel, A. K. et al. (2007). The best of both worlds: phase-reset of human EEG alpha activity and additive power contribute to ERP generation. Int J Psychophysiol, 65(1), 58-68.

Rihs, T. A., Michel, C. M., & Thut, G. (2007). Mechanisms of selective inhibition in visual spatial attention are indexed by alpha-band EEG synchronization. Eur J Neurosci, 25(2), 603-610.

Mnatsakanian, E. V. & Tarkka, I. M. (2007). Spatio-temporal modeling of evoked brain activity during memory encoding and target comparison in visual tasks. Brain Topogr, 20(1), 21-30.

Dien, J., Khoe, W., & Mangun, G. R. (2007). Evaluation of PCA and ICA of simulated ERPs: Promax vs. Infomax rotations. Hum Brain Mapp, 28(8), 742-763.

Rousselet, G. A., Husk, J. S., Bennett, P. J., & Sekuler, A. B. (2007). Single-trial EEG dynamics of object and face visual processing. Neuroimage, 36, 843-862.

Frank, R. M. & Frishkoff, G. A. (2007). Automated protocol for evaluation of electromagnetic component separation (APECS): application of a framework for evaluating statistical methods of blink extraction from multichannel EEG. Clinical Neurophysiology, 118, 80-97.

Fan, J., Kolster, R., Ghajar, J., Suh, M., Knight, R. T., Sarkar, R. et al. (2007). Response anticipation and response conflict: an event-related potential and functional margnetic resonance imaging study. Journal of Neuroscience, 27, 2272-2282.