Neurophysiology in the BrainWhereas conventional EEG could only show the brain's electrical activity as it was propagated to the head surface, computational methods of source estimation registered to the MRI image of head anatomy are now being validated for clinical use (Lantz et al., 2003; Michel et al., 1999; 2004; Tucker et al., 2007), and refined for implementation within the workflow of a busy clinical laboratory.
(Click here to learn more about EGI's GeoSource source estimation package.)
The result is localization of pathological physiological events with exact registration with the MRI that provides visualization of pathological anatomy (Seeck et al., 2001).
Lantz, G., Spinelli, L., Seeck, M., de Peralta Menendez, R. G., Sottas, C. C., & Michel, C. M. (2003). Propagation of interictal epileptiform activity can lead to erroneous source localizations: a 128-channel EEG mapping study. Journal of Clinical Neurophysiology, 20, 311-319. Michel, C. M., Grave de Peralta, R., Lantz, G., Gonzalez Andino, S., Spinelli, L., Blanke, O. et al. (1999). Spatiotemporal EEG analysis and distributed source estimation in presurgical epilepsy evaluation. J Clin Neurophysiol, 16(3), 239-66. Michel, C. M., Murray, M. M., Lantz, G., Gonzalez, S., Spinelli, L., & Grave de Peralta, R. (2004). EEG source imaging. Clin Neurophysiol, 115(10), 2195-2222. Seeck, M., Michel, C. M., Spinelli, L., & Lazeyras, F. (2001). EEG mapping and functional MRI in presurgical epilepsy evaluation. Rev Neurol (Paris), 157(8-9 Pt 1), 747-51. Tucker, D. M., Brown, M., Luu, P., & Holmes, M. D. (2007). Discharges in ventromedial frontal cortex during absence spells. Epilepsy and Behavior, 11, 546-557. |